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KMID : 0369819730030030305
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Jorunal of Korean Pharmaceutical Sciences
1973 Volume.3 No. 3 p.305 ~ p.315
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Study on Stabilization of Promazine Hydrochloride Injection
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이완하/Lee WH
지웅길/양재헌/Chi UK/Young JH
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Abstract
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The stabilizing effect of promazine hydrochloride injectin was tested by irradiation of sun lamp(5,000 Lux) on their acid solution sealed in ampules under various stabilizers. The result of experimentation on the color change, the remaining proportion and the half life of promazine hydrochloride solution is as follows. 1. Instability of promazine hydrochloride solution is mainly caused by the sunlight and oxygen. 2. The pH range of promazine hydrochloride injection is recommended to $pH\;4.4{\sim}5.2$ 수식 이미지 3. The decomposition of promazine hydrochloride by the sunlight is composed of pseudo zero order reaction when It maintains colorless solution. 4. The half life of 0.5% promazine hydrochloride injection was 30 hrs. under sun lamp irradiation, but it was delayed to 84 hrs. by the simple stabilizer and to 175 hrs. by compound stabilizer. 5. The stabilizing effect of promazine .hydrochloride injection adding sod. metabisulfite$(Na_2S_2O_5)$ 수식 이미지 was most excellent in various simple stabilizers and adding $Na_2S_2O_5$ 수식 이미지 to nicotinic acid, $Na_2S_2O_5$ 수식 이미지 to nicotinamide were more excellent than other compound stabilizers.
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